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cidec

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Official Full Name
cell death-inducing DFFA-like effector c
Background
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified.
Synonyms
cell death-inducing DFFA-like effector c; CIDEC; FSP27; CIDE-3; FLJ20871; cell death activator CIDE-3; OTTHUMP00000158645; OTTHUMP00000207602; fat specific protein 27; Cell Death Inducing DFFA Like Effector C; Cell death inducing DFFA like effector protein C; Cell death-inducing DFFA-like effector protein C; CIDE3; CIDEC_HUMAN; Fat-specific protein FSP27 homolog; CIDEX; CIDE 3; cell death activator CIDE-3-like; fat-specific protein FSP27-like protein