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chrna4

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Official Full Name
cholinergic receptor, nicotinic, alpha 4 (neuronal)
Background
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
Synonyms
CHRNA4; EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4; FLJ95812; ENFL1; cholinergic receptor, nicotinic, alpha 4; neuronal acetylcholine receptor subunit alpha-4; OTTHUMP00000031784; cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal nicotinic acetylcholine receptor alpha-4 subunit; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4 , EBN, EBN1; acetylcholine receptor; nicotinic; alpha 4 (neuronal); alpha-4 subunit, nicotinic acetylcholine receptor

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