Pancreastatin belongs to the chromogranin/secretogranin protein family, strongly inhibits glucose induced insulin release from the pancreas. The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
CHGA; chromogranin A (parathyroid secretory protein 1); chromogranin-A; SP-I; pituitary secretory protein I; parathyroid secretory protein 1; betagranin (N-terminal fragment of chromogranin A); CGA; Pancreastatin; parastatin; vasostatin; chromogranin A; fj05f09; zgc:56075; wu:fj05f09; zgc:101749; si:dkey-177p2.2