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chfr

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Official Full Name
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
Background
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]
Synonyms
CHFR; checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase; RNF116; RNF196; E3 ubiquitin-protein ligase CHFR; RING finger protein 196; fc43f10; wu:fc43f10; si:dkey-69h6.7; Checkpoint with forkhead and RING finger domains protein