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cfd

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Official Full Name
complement factor D (adipsin)
Background
Complement Factor D (CFD) is a 253 amino acid secreted protein that belongs to the peptidase S1 family. It contains 1 peptidase S1 domain. Complement Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement Factor D catalyzes the selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor. Defects in CFD are the cause of complement factor D deficiency (CFDD). CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
Synonyms
ADIPSIN; ADN; DF; PFD; C3 convertase activator; D component of complement (adipsin); complement factor D; complement factor D preproprotein; properdin factor D; CFD; complement factor D (adipsin); D component of complement (adipsin) , DF, PFD, properdin factor D; cfdl; wu:fb61f12; zgc:109940; fb61f12; complement factor D (adipsin) like