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cfc1

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Official Full Name
cripto, FRL-1, cryptic family 1
Background
This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in this gene can cause autosomal visceral heterotaxy. This protein is involved in left-right asymmetric morphogenesis during organ development.
Synonyms
CFC1; cripto, FRL-1, cryptic family 1; cryptic protein; CRYPTIC; HTX2; CFC 1; CR 1; Cripto 1; Cripto FRL 1 cryptic family 1; Cryptic family 1; Cryptic gene; FLJ77897; FRL 1; MGC133213; OTTHUMP00000204816; cryptic family protein 1; CFC1B; DTGA2