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cep170

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Official Full Name
centrosomal protein 170kDa
Background
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.
Synonyms
CEP170; centrosomal protein 170kDa; KIAA0470; centrosomal protein of 170 kDa; FAM68A; KAB; KARP 1 binding protein; XRCC5 binding protein; KARP-1-binding protein