Official Full Name
cyclin-dependent kinase inhibitor 1C
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
CDKN1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); BWS; WBS; p57; BWCR; KIP2; cyclin-dependent kinase inhibitor 1C; p57Kip2; cyclin-dependent kinase inhibitor p57; OTTHUMP- 00000011736; OTTHUMP00000011738; Beckwith- Wiedemann syndrome; OTTHUMP00000229152; cb961; p27Xic1-a; zgc:86618