CDK5 regulatory subunit-associated protein 3 (Cdk5rap3) is a recently described regulator for Cdk5 activity through interaction with CDK5R1. It may also have a role in cell proliferation. Recent studies have shown Cdk5rap3 to have a crucial role in regulating apoptosis induced by genotoxic stress by interacting with the G2/M DNA damage checkpoint. Expression of Cdk5rap3 is considered ubiquitous, and has been observed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
CDK5RAP3; CDK5 regulatory subunit associated protein 3; CDK5 regulatory subunit-associated protein 3; C53; FLJ13660; HSF 27; IC53; ischemic heart CDK5 activator binding protein C53; LXXLL/leucine zipper containing ARFbinding protein; LZAP; MST016; OK/SW cl.114; ischemic heart CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARFbinding protein; HSF-27; OK/SW-cl.114; cdkrap3; fb33h04; fc09c05; zgc:86863; id:ibd2920; wu:fb33h04; wu:fc09c05