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cdk5rap2

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Official Full Name
CDK5 regulatory subunit associated protein 2
Background
CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) potentially regulates CDK5 activity by interacting with CDK5R1. CDK5 is a brain specific cyclin-dependent kinase important to mammalian brain development. Studies implicate CDK5RAP2 involvement in centrosome directed production of microtubules and mitotic spindle formation during neuronal cell division. Mutations in CDK5RAP2 have been linked to the developmental disorder autosomal recessive primary microcephaly.
Synonyms
CDK5RAP2; CDK5 regulatory subunit associated protein 2; MCPH3, microcephaly, primary autosomal recessive 3; CDK5 regulatory subunit-associated protein 2; C48; CEP215; FLJ10867; centrosomal protein 215 kDa; centrosome-associated protein 215; CDK5 activator-binding protein C48; MCPH3; KIAA1633; DKFZp686B1070; DKFZp686D1070