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cdk2ap1

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Official Full Name
cyclin-dependent kinase 2 associated protein 1
Background
The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.
Synonyms
CDK2AP1; cyclin-dependent kinase 2 associated protein 1; CDK2 associated protein 1; cyclin-dependent kinase 2-associated protein 1; doc 1; DOC1; DORC1; p12DOC 1; ST19; CDK2 A1; CDK2-associated protein 1; CDKA1; CDKA1_HUMAN; Cyclin dependent kinase 2 associated protein 1; Deleted in oral cancer 1; DOC 1 related protein; DOC 1R; DOC-1; DOC1R; Putative oral cancer suppressor; OTTHUMP00000239636; OTTHUMP00000239637; OTTHUMP00000239638; OTTHUMP00000239639; OTTHUMP00000239640; Deleted in oral cancer-1; p12DOC-1