This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far.
CDK11A; cyclin-dependent kinase 11A; CDC2L2, CDC2L3, cell division cycle 2 like 2 , cell division cycle 2 like 2 (PITSLRE proteins); CDK11 p46; CDK11 p58; CDK11 p110; p58GTA; PITSLRE; CD11A_HUMAN; CDC2L2; CDC2L3; CDK11; CDK8 like cyclin dependent kinase; Cell division cycle 2 like protein kinase 2; Cell division cycle 2-like protein kinase 2; Cell division protein kinase 11A; Cyclin dependent kinase (CDC2 like) 11; Death preventing kinase; Galactosyltransferase associated protein kinase p58/GTA; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE protein kinase beta; PITSLRE serine/threonine-protein kinase CDC2L2; PITSLREB; serine/threonine-protein kinase CDC2L2; PITSLRE B; OTTHUMP00000000760; OTTHUMP00000000762; OTTHUMP00000000763; OTTHUMP00000000764; OTTHUMP00000000767; OTTHUMP00000000768; cell division cycle 2-like 2 (PITSLRE proteins); CDK11-p46; CDK11-p58; CDK11-p110