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cdca2

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Official Full Name
cell division cycle associated 2
Background
CDCA2 is a regulator of chromosome structure during mitosis. CDCA2 forms an essential complex with protein phosphatase PP1-gamma subunit 1 (PPP1CC) and is required for the recruitment of PP1 to chromatin. Knockdown of CDCA2 by RNAi causes large-scale cell death by apoptosis, as does overexpression of a dominant-negative mutant of the protein.
Synonyms
CDCA2; cell division cycle associated 2; Repo-Man; cell division cycle-associated protein 2; recruits PP1 onto mitotic chromatin at anaphase protein; protein phosphatase 1 [gamma] (PPP1R3A) binding protein Repo-Man