The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CDC27; cell division cycle 27 homolog (S. cerevisiae); APC3; HNUC; NUC2; ANAPC3; CDC27Hs; D0S1430E; D17S978E; cell division cycle protein 27 homolog; H-NUC; nuc2 homolog; CDC27 homolog; OTTHUMP00000232872; OTTHUMP00000232873; OTTHUMP00000232875; OTTHUMP00000232877; anaphase promoting complex subunit 3; anaphase-promoting complex subunit 3; anaphase-promoting complex, protein 3; cell division cycle 27 , D17S978E, D0S1430E; APC3, HNUC, NUC2, ANAPC3, CDC27Hs, D0S1430E, D17S978E; cell division cycle 27; cell division cycle 27 homolog; wu:fb54g06; wu:fc88c12