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cda

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Official Full Name
cytidine deaminase
Background
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
Synonyms
CDA; cytidine deaminase; CDD; Cytidine aminohydrolase; EC 3.5.4.5; small cytidine deaminase; cytosine nucleoside deaminase; zgc:77948