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cd30

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Official Full Name
tumor necrosis factor receptor superfamily, member 8
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms
CD 30; CD153 antibodyCD30; CD30 antigen; CD30L receptor; Cytokine receptor CD30; D1S166E; KI 1; Ki-1 antigen; KI1; Lymphocyte activation; antigen CD30; TNFRSF8; Tumor Necrosis Factor Receptor Superfamily Member 8; Iratumumab; 640735-09-7; Brentuximab vedotin; 914088-09-8; tumor necrosis factor receptor superfamily, member 8; CD30