The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
CD247; CD247 molecule; T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA; Preferred; T-cell surface glycoprotein CD3 zeta chain; OTTHUMP00000032543; OTTHUMP00000032544; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, zeta polypeptide (TiT3 complex); T-cell antigen receptor complex, zeta subunit of CD3; CD3Z, CD3z antigen, zeta polypeptide (TiT3 complex) , CD247 antigen; CD3zeta chain; TCR zeta chain; TCRzeta; TCR zeta chain subunit; cd3zeta; CD247 antigen