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ccl11

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Official Full Name
chemokine (C-C motif) ligand 11
Background
Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.[5] The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.
Synonyms
Ccl11; chemokine (C-C motif) ligand 11; Scya11; eotaxin; eotaxin-1; MGC22554; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); small inducible cytokine A11; C-C motif chemokine 11; Eosinophil chemotactic protein; SCYA11, small inducible cytokine subfamily A (Cys Cys), member 11 (eotaxin); eotaxin 1; small-inducible cytokine A11