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cbx2

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Official Full Name
chromobox homolog 2
Background
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
Synonyms
CBX2; chromobox homolog 2; M33; CDCA6; SRXY5; chromobox protein homolog 2; modifier 3; Pc class homolog; cell division cycle associated 6; chromobox homolog 2 (Pc class homolog, Drosophila); M33, CDCA6, SRXY5; chromobox homolog 2 (Drosophila Pc class); pc1; wu:fd20e09; zgc:103563

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