Official Full Name
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
CBLL1; Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1; E3 ubiquitin-protein ligase Hakai; Casitas B lineage lymphoma like; FLJ23109; HAKAI; RNF188; c-Cbl-like protein 1; Casitas B-lineage lymphoma transforming sequence-like protein 1; Casitas B-lineage lymphoma-like 1; Casitas B-lineage lymphoma-transforming sequence-like protein 1; HAKAI_HUMAN; RING finger protein 188; OTTHUMP00000206719; OTTHUMP00000206720; OTTHUMP00000206722; OTTHUMP00000206724; E-cadherin binding protein E7; Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; Cas Br M (murine) ecotropic retroviral transforming sequence like 1; MGC163401; MGC163403; Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase; zgc:55308