Official Full Name
caspase 12 (gene/pseudogene)
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
CASP12; UNQ9415; Apoptosis related cysteine protease; CASP 12; CASP-12; CASP12P1; Caspase 12 pseudogene 1; Caspase12; CASPC_HUMAN; Inactive caspase-12; inactive caspase-12-like; EC 3.4.22