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Official Full Name
cysteinyl-tRNA synthetase
Background
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.
Synonyms
CARS; cysteinyl-tRNA synthetase; cysteinyl-tRNA synthetase, cytoplasmic; CARS1; cysteine tRNA ligase 1; cytoplasmic; Cysteine tRNA ligase; CysRS; Cysteinyl tRNA synthetase, cytoplasmic; MGC:11246; cysteine translase; cysteine--tRNA ligase; cysteine tRNA ligase 1, cytoplasmic; cysteine--tRNA ligase, cytoplasmic; CARS1, CYSRS, MGC:11246, CARS; cysteine-tRNA ligase; sb:cb71

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