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cacna1d

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Official Full Name
calcium channel, voltage-dependent, L type, alpha 1D subunit
Background
Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarisation. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Voltage-gated calcium channels are formed from four or five distinct subunits; the alpha-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families. Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activateddihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type).
Synonyms
Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit; C79217; Cchl1a; D-LTCC; Cchl1a2; Cacnl1a2; 8430418G19Rik; voltage-dependent L-type calcium channel subunit alpha-1D; alpha 1 E; Cav1.3alpha1; calcium channel, L type, alpha-1 polypeptide; voltage-gated calcium channel subunit alpha Cav1.3; CHCACHA1D; L-type voltage-gated calcium channel alpha1D subunit ChCaChA1D