The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy.
C7ORF11; chromosome 7 open reading frame 11; TTD non-photosensitive 1 protein; non photosensitive 1; ORF20; tricothiodystrophy; TTDN1; ABHS; TTD nonphotosensitive 1 protein; Russell-Silver syndrome region