C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
complement C3; Acylation Stimulating Protein Cleavage Product; ASP; C3 and PZP like alpha 2 macroglobulin domain containing protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3; CO3_HUMAN; Complement C3 precursor; Complement C3c alpha' chain fragment 2; Complement Component 3; Complement factor 3; CPAMD 1; CPAMD1; C3d; complement component 3d; complement C3 alpha chain