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c1orf218

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Official Full Name
DENN/MADD domain containing 1B
Background
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members;of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early;endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024).;Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed;20154091)).
Synonyms
DENND1B; DENN/MADD domain containing 1B; C1orf218, chromosome 1 open reading frame 218 , FAM31B, family with sequence similarity 31, member B; DENN domain-containing protein 1B; FLJ20054; MGC27044; C1ORF18; C1orf218; Chromosome 1 open reading frame 218; DEN1B_HUMAN; DENN domain containing protein 1B; DENN MADD domain containing 1B; DKFZp547O0715; FAM31B; Family with sequence similarity 31 member B; FLJ21179; FLJ33888; MGC103810; Protein FAM31B; connecdenn 2; family with sequence similarity 31, member B; RP11-53I24.2