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brwd1

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Official Full Name
bromodomain and WD repeat domain containing 1
Background
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.
Synonyms
BRWD1; bromodomain and WD repeat domain containing 1; C21orf107, chromosome 21 open reading frame 107 , WD repeat domain 9 , WDR9; bromodomain and WD repeat-containing protein 1; FLJ11315; N143; Bromodomain and WD repeat domain containing protein 1; BRWD1_HUMAN; C21orf107; cAMP response element binding and beta tranducin family; chromosome 21 open reading frame 107; Response element binding and beta tranducin family like; Transcriptional unit N143; WD repeat protein; WD repeat protein WDR9 form2; WD repeat-containing protein 9; WDR9; WD repeat protein WDR9-form2