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bin1

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Official Full Name
bridging integrator 1
Background
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a;MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system;may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin.;Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and;activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in;cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different;isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Synonyms
BIN1; bridging integrator 1; AMPHL; myc box-dependent-interacting protein 1; AMPH2; amphiphysin II; SH3P9; amphiphysin-like protein; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; MGC10367; DKFZp547F068