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bex2

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Official Full Name
brain expressed X-linked 2
Background
This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
BEX2; brain expressed X-linked 2; protein BEX2; DJ79P11.1; BEX 1; BEX 2; BEX1; Brain expressed X linked 2; Brain expressed X linked protein 2 homolog; brain expressed X-linked 1; HBEX2; HGR74-h; uncharacterized hypothalamus protein HBEX2; X-linked protein; OTTHUMP00000023734; OTTHUMP00000023735; OTTHUMP00000023736; brain-expressed X-linked protein 2