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best3

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Official Full Name
bestrophin 3
Background
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in;vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM;607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of;aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene;structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron;boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 (PubMed;12032738); Tsunenari et al., 2003 (PubMed 12907679)).
Synonyms
BEST3; bestrophin 3; vitelliform macular dystrophy 2 like 3 , VMD2L3; bestrophin-3; MGC13168; MGC40411; Vitelliform macular dystrophy 2 like protein 3; BEST 3; BEST3_HUMAN; Bestrophin3; OTTHUMP00000195114; OTTHUMP00000233491; Vitelliform macular dystrophy 2 like 3; Vitelliform macular dystrophy 2-like protein 3; VMD2L3; vitelliform macular dystrophy 2-like 3