This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
BCCIP; BRCA2 and CDKN1A interacting protein; BRCA2 and CDKN1A-interacting protein; BCCIPalpha; TOK 1; BCCIP_HUMAN; BCCIPbeta; BRCA2 and Cip1/p21 interacting protein; Cdk inhibitor p21 binding protein; P21 and CDK associated protein 1; P21- and CDK-associated protein 1; Protein TOK-1; Protein TOK1; TOK 1alpha; TOK 1beta; TOK1; TOK-1beta; TOK-1alpha; TOK-1; TOK1, TOK-1; zgc:110272; mp:zf637-1-000774; protein BCCIP homolog