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bbc3

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Official Full Name
BCL2 binding component 3
Background
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Synonyms
BBC3; BCL2 binding component 3; JFY1; PUMA; JFY-1; bcl-2-binding component 3; p53 up-regulated modulator of apoptosis

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