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Official Full Name
apoptosis, caspase activation inhibitor
Background
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients.
Synonyms
AVEN; apoptosis, caspase activation inhibitor; PDCD12; cell death regulator aven; programmed cell death 12; OTTHUMP00000159733; Aven-like protein; wu:fc08c09; zgc:136239; si:ch211-150c22.4