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atp6v1c2

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Official Full Name
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms.
Synonyms
ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2; ATPase, H+ transporting, lysosomal 42kD, V1 subunit C isoform 2 , ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2; V-type proton ATPase subunit C 2; ATP6C2; VMA5; ATPase H+ transporting lysosomal 42kDa V1 subunit C2; V ATPase C2 subunit; V ATPase subunit C 2; V type proton ATPase subunit C 2; V-ATPase subunit C 2; Vacuolar ATP synthase subunit C 2; Vacuolar H+ ATPase C2; Vacuolar proton pump subunit C 2; VATC2_HUMAN; VMA 5; OTTHUMP00000115522; OTTHUMP00000200400; V-ATPase C2 subunit; VMA5, ATP6C2

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