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atp6v1b2

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Official Full Name
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.
Synonyms
ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; ATP6B2, ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta polypeptide, 56/58kD, isoform 2 , ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2 , VPP3; V-type proton ATPase subunit B, brain isoform; HO57; VATB; Vma2; ATP6B1B2; ATP6B2; ATP6V1 B2; ATP6V1B 2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B isoform 2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B2; ATPase H+ transporting, lysosomal (vacuolar proton pump) beta polypeptide 56/58kD isoform 2; ATPase, H+ transporting, lysosomal V1 subunit B2; Endomembrane proton pump 58 kDa subunit; H+ transporting two sector ATPase; HO 57; V ATPase B2 subunit; V ATPase subunit B 2; V type proton ATPase subunit B, brain isoform; Vacuolar ATP synthase subunit B brain isoform; Vacuolar H+ ATPase 56000 subunit; Vacuolar H+ATPase B2; Vacuolar proton pump subunit B 2; VAT B2; VATB 2; VATB2; Vma 2; VPP 3; VPP3; OTTHUMP00000161707; V-ATPase B2 subunit; V-ATPase subunit B 2; H+ transporting two-sector ATPase; vacuolar H+-ATPase 56,000 subunit; vacuolar H-ATPase B subunit osteoclast isozyme; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2; ATPase, H+ transporting, lysosomal, V1 subunit B2; fj51e01; atp6v1bb; wu:fj51e01; zgc:109771; ATPase, H+ transporting, lysosomal 56/58kDa, V1

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