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atp6v0b

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Official Full Name
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
Synonyms
ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b; ATP6F, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21kD , ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c; V-type proton ATPase 21 kDa proteolipid subunit; HATPL; VMA16; ATP6F; V-ATPase 21 kDa proteolipid subunit; Vacuolar proton pump 21 kDa proteolipid subunit; VATO_HUMAN; V-ATPase subunit c; vacuolar proton pump, 21 kDa subunit; H(+)-transporting two-sector ATPase, subunit F; vacuolar ATP synthase 21 kDa proteolipid subunit; ATPase, H+ transporting, lysosomal V0 subunit b; zgc:63832; wu:fb33a01; ATPase, H+ transporting, V0 subunit B