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atp1a2

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Official Full Name
ATPase, Na+/K+ transporting, alpha 2 polypeptide
Background
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.
Synonyms
ATP1A2; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide , MHP2, migraine, hemiplegic 2; sodium/potassium-transporting ATPase subunit alpha-2; FHM2; KIAA0778; Na+/K+ATPase alpha 2 subunit; AT1A2_HUMAN; MHP2; Na(+)/K(+) ATPase alpha-2 subunit; Sodium potassium ATPase; Sodium pump subunit alpha 2; Sodium pump subunit alpha-2; Sodium/potassium transporting ATPase alpha 2 chain; Sodium/potassium transporting ATPase subunit alpha 2; sodium-potassium ATPase; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; sodium/potassium-transporting ATPase alpha-2 chain; MGC59864; Na,K-ATPase alpha-2-subunit; ATPase, Na+/K+ transporting, alpha 2 (+) polypepti; ATP2A