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asb7

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Official Full Name
ankyrin repeat and SOCS box containing 7
Background
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described.
Synonyms
ASB7; ankyrin repeat and SOCS box containing 7; ankyrin repeat and SOCS box protein 7; Ankyrin repeat and SOCS box containing protein 7; ASB 7; ASB-7; ankyrin repeat and SOCS box-containing 7; FLJ22551; FLJ25192; ankyrin repeat and SOCS box-containing protein 7; zgc:77381