This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants.
ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; DDEFL1, development and differentiation enhancing factor like 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3; centaurin; beta 6; CENTB6; FLJ20199; UPLC1; centaurin,; centaurin, beta 6; ARF6 GTPase-activating protein; protein up-regulated in liver cancer 1; up-regulated in liver cancer 1 (UPLC1); development and differentiation enhancing factor-like 1; development and differentiation-enhancing factor-like 1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 1; ACAP4; DDEFL1; zgc:113885