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arhgef26

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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 26
Background
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms
ARHGEF26; Rho guanine nucleotide exchange factor (GEF) 26; rho guanine nucleotide exchange factor 26; DKFZP434D146; SGEF; Src homology 3 domain containing guanine nucleotide exchange factor; SH3 domain-containing guanine exchange factor; Src homology 3 do; CSGEF; HMFN1864