Official Full Name
Rho guanine nucleotide exchange factor (GEF) 11
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
ARHGEF11; Rho guanine nucleotide exchange factor (GEF) 11; rho guanine nucleotide exchange factor 11; GTRAP48; KIAA0380; PDZ RHOGEF; ARHGB_HUMAN; ARHGEF 11; DKFZp667F1223; Glutamate transporter EAAT4 associated protein 48; GTRAP 48; OTTHUMP00000038716; OTTHUMP00000038717; PDZ-RhoGEF; Rho guanine exchange factor (GEF) 11; RhoA specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator; RhoA-specific guanine nucleotide exchange factor; glutamate transporter EAAT4-associated protein 48