Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM;179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization,;and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly;regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine;nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the;rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 (PubMed 8356058)).
ARHGDIB; Rho GDP dissociation inhibitor (GDI) beta; GDIA2, GDID4, RAP1GN1; rho GDP-dissociation inhibitor 2; Ly GDI; RhoGDI2; Rho GDI 2; rho-GDI beta; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1