Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene.
ARHGAP26; Rho GTPase activating protein 26; rho GTPase-activating protein 26; GRAF; GTPase regulator associated with the focal adhesion kinase pp125; KIAA0621; OPHN1L; OPHN1L1; oligophrenin-1-like protein; GTPase regulator associated with focal adhesion k; GTPase regulator associated with focal adhesion kinase pp125(FAK); GRAF1; FLJ42530; rhoGap protein; rho-type GTPase-activating protein 26; GTPase regulator associated with focal adhesion kinase