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areg

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Official Full Name
amphiregulin
Background
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
Synonyms
AREG; amphiregulin; schwannoma derived growth factor , SDGF; AR; Colorectum cell derived growth factor; CRDGF; A REG; MGC13647; Schwannoma derived growth factor; SDGF; OTTHUMP00000160473; OTTHUMP00000219184; schwannoma-derived growth factor; colorectum cell-derived growth factor; AREGB

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