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arap1

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Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Background
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
ARAP1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; centaurin, delta 2 , CENTD2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ANK repeat and PH domain-containing protein 1; mKIAA0782; 2410002L19Rik; ARAP 1; ARAP1_HUMAN; Arf GAPRho GAP ankyrin repeat and pleckstrin homology domains containing protein 1; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1; Arf-GAP with Rho-GAP domain; CENT D2; Centaurin delta 2; Centaurin delta2; Centaurin-delta-2; CENTD 2; CENTD2; Cnt d2; Cnt-d2; Cntd2; KIAA0782; MGC176140; OTTHUMP00000211458; OTTHUMP00000211459; OTTHUMP00000211460; OTTHUMP00000211461; OTTHUMP00000211462; OTTHUMP00000211463; centaurin, delta 2; ARF-GAP, RHO-GAP, anky

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