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apbb1

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Official Full Name
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Background
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the;nucleus. It interacts with the Alzheimers disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1;and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent;the gene products nuclear translocation. This encoded protein could play an important role in the pathogenesis of;Alzheimers disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by;downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different;isoforms have been described for this gene.
Synonyms
APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); RIR; amyloid beta A4 precursor protein-binding family B member 1; Fe65; stat-like protein; adaptor protein FE65a2; MGC:9072