Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described.
ANXA6; annexin A6; ANX6; CBP68; 67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70; calelectrin; calphobindin II; annexin VI (p68); OTTHUMP00000226119; OTTHUMP00000226120; OTTHUMP00000226122; calcium-binding protein p68e; calcium-binding protein p68; calcium- and phospholipid-binding protein; lipid-dependent Ca(2+)-binding protein annexin VI; ANX VI; annexin 6