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als2cr2

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Official Full Name
STE20-related kinase adaptor beta
Background
Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2, is connected to transferase/kinase activity and ATP binding, it has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1 converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.
Synonyms
Stradb; STE20-related kinase adaptor beta; Papk; ILPIP; ILPIPA; Syradb; Als2cr2; D1Ucla2; PRO1038; AA792893; B830008M19; STE20-related kinase adapter protein beta; STRAD beta; OTTMUSP00000022732; pseudokinase ALS2CR2; ILP-interacting protein homolog; polyploidy associated protein kinase; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; Polyploidy-associated protein kinase; ALS2CR2, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; CALS 21; ILP-interacting protein ILPIPA; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; MGC102916