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alox5ap

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Official Full Name
arachidonate 5-lipoxygenase-activating protein
Background
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Synonyms
ALOX5AP; arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein; five lipoxygenase activating protein; MK 886 binding protein; fj65d02; zgc:63982; wu:fj65d02