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alg12

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Official Full Name
ALG12, alpha-1,6-mannosyltransferase
Background
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the;eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor;(dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with;congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation.
Synonyms
ALG12; asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae); asparagine linked glycosylation 12 homolog (yeast, alpha 1,6 mannosyltransferase); dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; ECM39; membrane protein SB87; mannosyltransferase ALG12 homolog; asparagine-linked glycosylation protein 12 homolog; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase; dolichyl-P-mannose:Man-7-GlcNAc-2-PP-dolichyl-alpha-6-mannosyltransferase; asparagine-linked glycosylation 12 homolog (yeast, alpha-1,6-mannosyltransferase); asparagine-linked glycosylation 12 homolog (S. cerevisiae, alpha-1,6-mannosyltransferase); CDG1G; hALG12; PP14673; MGC3136; MGC111358; CDG1G, ECM39, hALG12, PP14673, MGC3136, MGC111358, ALG12; alpha-1; 6-mannosyltransferase); alpha-1,6-mannosyltransferase ALG12; 6-mannosyltransferase ALG12; asparagine-linked glycosylation 12 homolog (yeast, alpha-1; ALG12, alpha-1,6-mannosyltransferase; si:dkey-164m14.3